PPP1R3G-Mediated Necroptosis
Tubular cell injury is a major driver of acute and chronic kidney disease. SWL is investigating how PPP1R3G and PP1γ regulate RIPK1 activation and how selective peptidomimetics may block RIPK1-dependent cell death.
Research & Development
Science
SWL Therapeutics advances renal and transplant medicine through programs focused on regulated cell death, graft function, organ preservation, and clinically relevant models of kidney injury.
Transplantation Research & Renal Pathophysiology
Protecting kidney function from molecular injury to organ preservation
Our work connects mechanistic kidney biology with translational strategies designed to reduce tissue injury, preserve graft viability, and improve post-transplant outcomes.
Core focus
Kidney disease, ischemic injury, and transplant graft function
Translation
Peptidomimetic therapeutics, organ preservation, and large-animal validation
Models
Cellular mechanisms, rodent transplantation, porcine transplant models, and machine perfusion
Macula Densa NOS1β
Research into macula densa NOS1β explores how urinary pH and tubuloglomerular feedback influence transplanted kidney graft function and post-transplant renal outcomes.
SMEF Organ Preservation
Synchronization Modulation Electric Field, or SMEF, is being developed to help sustain Na+/K+-ATPase activity during ATP-deficient stress, with the goal of reducing ischemic kidney injury during donor organ storage.
Kidney-Liver Crosstalk
Studies of metabolic-associated steatohepatitis and chronic kidney disease examine how liver pathology can contribute to renal injury, including through transplantation models that separate hepatic and kidney-specific effects.
Large-Animal Models
Clinically relevant porcine models, including transplantation, ischemia-reperfusion injury, and machine perfusion, provide a translational platform for evaluating graft viability and preservation strategies.
Therapeutic Strategy
Across these programs, SWL Therapeutics aims to convert mechanistic insight into practical interventions that protect organs, improve graft performance, and reduce kidney disease progression.